Author

Jessica Beasley

University of Leicester

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam Cryar· 1 shared Adriana OrdóñeziD· 1 shared Aleck W.E. Jones· 1 shared Bibek GooptuiD· 1 shared Charis‐Patricia Segeritz· 1 shared David A. LomasiD· 1 shared Graeme C. Smith· 1 shared Imran Haq· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Adam Cryar

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1 paper

Recent·Most cited

Both terminal misfolding and polymerisation contribute to disease-relevant phenotypic changes in cell models of alpha-1-antitrypsin deficiency-associated liver disease

Panayiota Stylianou, Kish R. Adoni, Mun Peak Nyon, Adam Cryar, Imran Haq, Jennifer A. Dickens, Charis‐Patricia Segeritz, Graeme C. Smith, Adriana Ordóñez, James A. Irving, David A. Lomas, Kyra-Mae Leighton, Jessica Beasley, Aleck W.E. Jones, S. Tamir Rashid, , Bibek Gooptu

This study shows that both terminal misfolding and polymerisation of Z 1-antitrypsin contribute to liver disease phenotypes, with terminal misfolding driving pro-fibrotic responses and metabolic changes.

bioRxiv · Sep 30, 2025 · PreprintCell Biology