Ex vivo recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human Lymphoid Follicle Chip platform
Yunhao Zhai, Min‐Wen Ku, Ka Yang, Aditya Patil, Pranav Prabhala, Lirong He, Yuncheng Man, Sven B. Spörri, Supriya Gharpure, Abdul Rahman Isaacs, Shay Ferdosi, Andrzej S. Pitek, Giulietta Maruggi, Sylvie Bertholet, Jessica L. Firestone, , Girija Goyal
This paper develops a human lymphoid follicle chip platform to model intramuscular mRNA vaccine responses, showing it can replicate immune responses to both naive and recall antigens.
bioRxiv · Apr 16, 2025 · PreprintImmunology