Structure-Activity Relationship and Target Investigation of Thiophen-2-yl-Pyrimidines against Schistosoma species
Karol R. Francisco, Bobby Lucero, Darius J. Yohannan, Carmine Varricchio, Anny Lam, Jessica Sebastiani, Lawrence J. Liu, Yujie Uli Sun, Jorge Jacinto, Michele Renzulli, Ludovica Monti, Alexis Lona, Irina Kufareva, Andrea Brancale, Carlo Ballatore, , Conor R. Caffrey
This paper identifies a new class of thiophen-2-yl pyrimidines (TPPs) with improved solubility and potency against Schistosoma species, suggesting novel targets beyond tubulin.
bioRxiv · Oct 7, 2025 · PreprintMicrobiology