Carmine Varricchio

This paper identifies a folding intermediate of Cyclin D1 as a target for selective degradation, showing that pharmacological interference with this state inhibits tumor growth and overcomes resistance to CDK4/6 inhibitors.

This study conjugates bexarotene to dextrin to improve its solubility and in vitro potency but finds it does not reduce lipid toxicity in vivo.

This paper identifies a new class of thiophen-2-yl pyrimidines (TPPs) with improved solubility and potency against Schistosoma species, suggesting novel targets beyond tubulin.