Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.
Jakub Lukaszonek, Najmeeyah Brown, Jessie Zenga, Elmarie Myburgh, James P. Hewitson, George Hajishengallis, Triantafyllos Chavakis, Paul Martin Kaye, Ioannis Kourtzelis
This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.
bioRxiv · Apr 24, 2024 · PreprintImmunology