Paul Martin Kaye

A single-cell transcriptomic atlas of peripheral blood immune cells spanning progressive canine leishmaniosis

The paper creates a single-cell RNA sequencing atlas of immune cells in dogs with progressive canine leishmaniosis, identifying immune cell phenotypes and transcriptional states associated with disease progression.

Ontogeny-independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis

The paper uses multimodal imaging and single-cell transcriptomics to identify LPCAT2-mediated membrane remodeling in granuloma macrophages during visceral leishmaniasis.

Spatial profiling of central nervous system cellular markers in murine breast cancer to brain metastases

The paper uses spatial profiling to analyze cellular marker changes in murine brain metastases, identifying upregulated immune markers and downregulated neuronal markers.

Bi-directional highways and super-seeder tissues underpin parasite dissemination in experimental visceral leishmaniasis.

This study maps parasite dissemination patterns in visceral leishmaniasis using a barcoded library and ecological analysis, revealing bi-directional highways and super-seeder tissues.

Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype

This study shows that platelet depletion in schistosomiasis leads to severe bleeding and reduced survival, while platelets do not directly drive macrophage activation in type 2 inflammation.

DIANNeR: label-free RIME resolves lineage-restricted Glucocorticoid Receptor interactomes in normal human tissues

DIANNeR improves detection of GR interactomes in normal tissues by integrating DIA, ion mobility, and library-free analysis, revealing context-specific networks and previously undetected interactions.

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.