Triantafyllos Chavakis

This paper identifies transient GSK3β activation as a mechanism promoting disease tolerance to sepsis through hypometabolism, without affecting pathogen burden.

This study evaluates tasquinimod's efficacy in MDS by showing it reduces inflammation, improves erythropoiesis, and enhances bone health in a mouse model.

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.

This study identifies AZIN2 as a regulator of adipocyte progenitor fate through polyamine metabolism, showing its protective role against obesity and metabolic dysfunction.

The paper identifies early metabolic imbalances as drivers of phenotypic variation in stembryos and shows how metabolic interventions can correct aberrant morphology and lineage bias.

This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.

This study shows that reduced endoglin in bone marrow endothelial cells causes vascular remodeling and hematopoietic changes, similar to those in hereditary hemorrhagic telangiectasia.

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.

This study shows that PHD2-HIF2 pathway regulates epinephrine synthesis and release in mouse adrenal glands, linking hypoxia signaling to catecholamine production and systemic glucose levels.

This study shows HIF1α is crucial for steroid hormone production in adrenal cells, with its absence increasing steroid levels and overexpression reducing them, affecting systemic health.

This paper presents a validated shotgun lipidomics method for adipose tissue, revealing diet-related lipidomic differences in brown, gonadal, and inguinal subcutaneous fat from lean and obese mice.