Author

Jakub Lukaszonek

University of York

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Andrew N. HoldingiD· 2 shared Ioannis KourtzelisiD· 2 shared Katherine S. BridgeiD· 2 shared Adam C. WilkinsoniD· 1 shared Adele Kay FieldingiD· 1 shared Alexandros ChatzisiD· 1 shared Andrew S. MasoniD· 1 shared Andy G.X. ZengiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Andrew N. HoldingORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

David Kealy, Ruth Ellerington, Suraj Bansal, Jessie J.F. Medeiros, Catherine A. Hawley, Andy G.X. Zeng, Jakub Lukaszonek, Katie A. West, Aparna D. Sinha, Gillian Caalim, Richard T. Gawne, Jacob Pope, B. Rodriguez Lima Ferreira, Nicole-Mae Geli Blacknell, Bryce Drylie, , Katherine S. Bridge

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

Leukemia · Feb 2, 2026Peer-reviewedCancer Biology

An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer

Jodie R. Malcolm, Jack Stenning, Jacob Pope, Jakub Lukaszonek, Susanna F Rose, Taylor E. Smith, Lesley Gilbert, Sally R. James, Katherine S. Bridge, William J. Brackenbury, Andrew N. Holding

The paper identifies an ERα-dependent hypoxia response in ER+ breast cancer that influences gene expression and sensitivity to amiloride, linking hypoxia and ER signaling.

bioRxiv · Oct 3, 2025 · PreprintCancer Biology

β-glucan reprograms macrophages to attenuate efferocytosis of cancer cells

Alexandros Chatzis, Jakub Lukaszonek, Dimitris Lagos, Dave Boucher, Ioannis Kourtzelis

This study shows that β-glucan induces trained innate immunity in macrophages, reducing their efferocytosis of cancer cells and altering inflammatory responses.

bioRxiv · Nov 11, 2024 · PreprintImmunology

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.

Jakub Lukaszonek, Najmeeyah Brown, Jessie Zenga, Elmarie Myburgh, James P. Hewitson, George Hajishengallis, Triantafyllos Chavakis, Paul Martin Kaye, Ioannis Kourtzelis

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.

bioRxiv · Apr 24, 2024 · PreprintImmunology