James P. Hewitson

Sex-specific lymphoid lineage differentiation is modulated by CIZ1

This study shows CIZ1 modulates sex-specific lymphoid lineage differentiation by affecting X-chromosome inactivation and autosomal gene expression in males and females.

Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype

This study shows that platelet depletion in schistosomiasis leads to severe bleeding and reduced survival, while platelets do not directly drive macrophage activation in type 2 inflammation.

Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer (NK) cells.

This study identifies a non-canonical inflammasome in human NK cells that mediates anti-microbial responses against Salmonella without canonical inflammasome components.

Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL2

This study shows Malat1 regulates cytokine expression in female Th2 cells by affecting early differentiation and IL2 response, but not in male cells.

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.