Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages
Marlene Cano, Fuyi Liao, Dequan Zhou, Catherine Chen, Zhiyi Liu, Ji Hong Zhu, Cory T. Bernadt, Ricky Ebenezer, Victoria R. Davis, K. Pugh, Yan Tao, Laneshia K. Tague, Howard J. Huang, Derek E. Byers, Ramsey R. Hachem, , Andrew E. Gelman
This study shows that the ATG16L1 genetic variant impairs macrophage metabolism, leading to lung transplant rejection, and suggests targeting glycolysis could prevent chronic lung allograft dysfunction.
bioRxiv · Oct 2, 2025 · PreprintImmunology