Yan Tao

Molecular Imaging of the TGF-β Activating Integrin αvβ6 Detects Chronic Lung Allograft Dysfunction

The paper uses molecular imaging to detect chronic lung allograft dysfunction by targeting the TGF-β-activating integrin αvβ6 in mouse and human lung transplants.

Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation.

This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.

Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages

This study shows that the ATG16L1 genetic variant impairs macrophage metabolism, leading to lung transplant rejection, and suggests targeting glycolysis could prevent chronic lung allograft dysfunction.