Derek E. Byers

The paper uses molecular imaging to detect chronic lung allograft dysfunction by targeting the TGF-β-activating integrin αvβ6 in mouse and human lung transplants.

This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.

This study shows that the ATG16L1 genetic variant impairs macrophage metabolism, leading to lung transplant rejection, and suggests targeting glycolysis could prevent chronic lung allograft dysfunction.

This study identifies HSP70 as a chaperone that facilitates the secretion and activity of the IL-33{Delta}34 isoform in chronic airway diseases.

This study characterizes donor lungs used for research, finding higher prevalence of diabetes, smoking, and non-intravenous drug use compared to transplant lungs.

The paper identifies a first-in-kind MAPK13 inhibitor that corrects stem cell reprogramming and reduces muco-obstructive lung disease symptoms in mice.

This study identifies MAPK13 as a regulator of structural remodeling and disease after epithelial injury, showing its role in basal-epithelial stem cell hyperplasia and mucous metaplasia in both mouse and human models.