Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility
Charles Ng, Tak Shun Fung, Dayi Li, Korbinian Nepomuk Kropp, Luis F. Somarribas Patterson, Alexandria Markovitz, Daniel N. Weinberg, Olivia Jones, Ji-Young Kim, Guoan Zhang, Richard P. Koche, Mara Monetti, Huayuan Tang, Yun He, Zhengshuang Xu, , Craig B. Thompson
This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.
bioRxiv · Mar 28, 2026 · PreprintImmunology