Author

Tak Shun Fung

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-9708-0937Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandria Markovitz· 1 shared Amrapali GhoshiD· 1 shared Charles NgiD· 1 shared Christopher Austin KlebanoffiD· 1 shared Craig B. ThompsoniD· 1 shared Daniel N. WeinbergiD· 1 shared Dayi LiiD· 1 shared Dhaval K ShukaliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

Alexandria Markovitz

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2 papers

Recent·Most cited

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

Charles Ng, Tak Shun Fung, Dayi Li, Korbinian Nepomuk Kropp, Luis F. Somarribas Patterson, Alexandria Markovitz, Daniel N. Weinberg, Olivia Jones, Ji-Young Kim, Guoan Zhang, Richard P. Koche, Mara Monetti, Huayuan Tang, Yun He, Zhengshuang Xu, , Craig B. Thompson

This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.

bioRxiv · Mar 28, 2026 · PreprintImmunology

Peri-mitochondrial actin filaments inhibit Parkin assembly via disruption of ER-mitochondrial contact

Tak Shun Fung, Amrapali Ghosh, Maite Zavala, Zuzana Nichtová, Dhaval K Shukal, Marco Tigano, György Csordás, Henry N. Higgs, Rajarshi Chakrabarti

The paper shows that peri-mitochondrial actin filaments (ADA) inhibit Parkin assembly by disrupting ER-mitochondrial contacts, delaying mitophagy after acute damage and blocking it during chronic dysfunction.

EMBO Reports · Aug 29, 2025Peer-reviewedCell Biology