Author

Guoan Zhang

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexandria Markovitz· 1 shared Anthony W. P. FitzpatrickiD· 1 shared Arshdeep SinghiD· 1 shared Carolyn L. Lee· 1 shared Charles NgiD· 1 shared Christopher Austin KlebanoffiD· 1 shared Craig B. ThompsoniD· 1 shared Daniel N. WeinbergiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperImmunology

Alexandria Markovitz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.

Myung Soo Ko, Henry Withers, Divya Ramchandani, Jason McCormick, Sebastian E. Carrasco, Pius Amartey, Arshdeep Singh, Liron Yoffe, Glenn E. Simmons Jr., Guoan Zhang, Wen Hong Shen, Vivek Mittal

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

bioRxiv · Oct 30, 2026 · PreprintCancer Biology✦ In-depth digest

Amyloid-mediated RNA uptake by sperm for embryonic delivery

William S. Mallen, Nataliya Zabello, Susan Brenner‐Morton, Simone Sidoli, Dr Fengxia Liang, Joseph Sall, Jason Yin, Priyanka Mathews, Mengmeng Zhu, Guoan Zhang, Carolyn L. Lee, Ya-Cheng Liao, Anthony W. P. Fitzpatrick

This study identifies amyloid fibrils in seminal fluid that bind and deliver RNA to sperm and the zygote during fertilization.

Molecular Cell · Oct 1, 2026Peer-reviewedBiophysics

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

Charles Ng, Tak Shun Fung, Dayi Li, Korbinian Nepomuk Kropp, Luis F. Somarribas Patterson, Alexandria Markovitz, Daniel N. Weinberg, Olivia Jones, Ji-Young Kim, Guoan Zhang, Richard P. Koche, Mara Monetti, Huayuan Tang, Yun He, Zhengshuang Xu, , Craig B. Thompson

This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.

bioRxiv · Mar 28, 2026 · PreprintImmunology