Maintenance DNA methylation is necessary for age-related alterations in regulatory T cell transcriptional and DNA methylation signatures
Jonathan K. Gurkan, Qianli Liu, Carla Patricia Reyes Flores, Kathryn A. Helmin, Daniel Herald Ryan, Anthony M. Joudi, Benjamin J. Ulrich, Hiam Abdala‐Valencia, Elizabeth M. Steinert, Benjamin David Singer
The paper investigates the role of maintenance DNA methylation in age-related changes in Treg cell transcriptional and DNA methylation signatures using UHRF1-deficient mice.
bioRxiv · Jun 29, 2026 · PreprintImmunology