Author

Jian Lu

Zhongda Hospital Southeast UniversityPrimary ORCID profile (0000-0002-0267-9243 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jian LuiD1 paper · Shanghai University of Traditional Chinese Medicine

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Baoyi Zhang· 1 shared Bin XuiD· 1 shared Bo Zhou· 1 shared Chuanjun ShuiD· 1 shared Chunyan Chu· 1 shared Dingxiao ZhangiD· 1 shared Haochen Long· 1 shared Haoyu Li· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Baoyi Zhang

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cortex-wide single-cell activity mapping in freely moving mice

郭长亮 Guo Changliang, Mian Xie, 邱国华, Jian Lu, Yuzhen Liu, Liying Qu, 黄园园 Huang Yuanyuan, Zhenran Guo, Jingren Lin, Jingren Lin, Baoyi Zhang, Xuefei Zhang, Junjie Zhao, Xiang Liu, Haochen Long, , Liangyi Chen

The paper introduces COMET, a lightweight head-mounted mesoscope for cortex-wide single-cell calcium imaging in freely moving mice, demonstrating its ability to capture neural activity during natural behaviors.

bioRxiv · Oct 15, 2026 · PreprintNeuroscience

Guidance for high-quality functional gene embeddings from large language models

Rongyao Huang, Yaopan Hou, Wuye Zhao, Junbing Zhang, Jian Lu, Yimeng Kong, Peng Xu

This study evaluates gene embeddings from large language models and finds that functional descriptions yield high-quality, biologically meaningful representations.

bioRxiv · May 4, 2026 · PreprintBioinformatics

YY1 Enhances the Stability of HIF-1α Protein by Interacting with NUSAP1 in Macrophages within the Prostate Cancer Microenvironment

Wenchao Li, Saisai Chen, Jian Lu, Weipu Mao, Shiya Zheng, Minhao Zhang, Tiange Wu, Yurui Chen, Kai Lu, Chunyan Chu, Chuanjun Shu, Yue Hou, Xue Yang, Naipeng Shi, Zhijun Chen, , Bin Xu

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

Nature Communications · Jul 7, 2025Peer-reviewedCancer Biology✦ In-depth digest