Author

Saisai Chen

University of Science and Technology of ChinaORCID 0000-0002-7262-7051Unclaimed ORCID profile · follow to get notified of new preprints

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Saisai Chen1 paper

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Bin XuiD· 1 shared Chuanjun ShuiD· 1 shared Chunyan Chu· 1 shared Dingxiao ZhangiD· 1 shared Jian Lu· 1 shared Kai Lu· 1 shared Lei ZhangiD· 1 shared Lihua ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Bin XuORCID

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1 paper

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedJul 7, 2025

✦ In-depth digest

YY1 Enhances the Stability of HIF-1α Protein by Interacting with NUSAP1 in Macrophages within the Prostate Cancer Microenvironment

Wenchao Li, Saisai Chen, Jian Lu…·Bin Xu

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

28 citationstop 1%

humanmouse

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