Yuzhen Liu

Cortex-wide single-cell activity mapping in freely moving mice

The paper introduces COMET, a lightweight head-mounted mesoscope for cortex-wide single-cell calcium imaging in freely moving mice, demonstrating its ability to capture neural activity during natural behaviors.

DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

DNA O-MAP identifies molecular neighborhoods around specific genomic loci using programmable probes and proteomics.

Efficient and highly amplified imaging of nucleic acid targets in cellular and histopathological samples with pSABER

The paper introduces pSABER, a method for amplifying in situ hybridization signals in cellular and histopathological samples, achieving 25-fold amplification over conventional methods.

Patterns of Structural Variation Define Prostate Cancer Across Disease States

This study identifies distinct structural variation patterns in prostate cancer across disease states, defining clinically actionable subgroups based on whole genome profiling.

PaintSHOP enables the interactive design of transcriptome- and genome-scale oligonucleotide FISH experiments

PaintSHOP provides an interactive platform for designing oligonucleotide FISH experiments, integrating machine learning to predict probe specificity and generate standardized probe sets.