Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells
Zhuoyi Liang, Vipul Kumar, Marie Le Bouteiller, Jeffrey Zurita, Josefin Kenrick, Sherry G. Lin, Jiangman Lou, Jianqiao Hu, Adam Yongxin Ye, Cristian Boboilă, Frederick W. Alt, Richard L. Frock
The paper shows that Ku70 suppresses alternative end-joining (A-EJ) in G1-arrested progenitor B cells, directing DSB repair toward classical nonhomologous end-joining (C-NHEJ) and preventing translocations.
Proceedings of the National Academy of Sciences · May 18, 2021Peer-reviewedGenetics