Jianqiao Hu

This paper develops six mouse models with engineered antibody repertoires to study and optimize strategies for inducing HIV-1 broadly neutralizing antibodies.

The paper demonstrates that a virtual animal combining a worm connectome and fly biomechanics can produce realistic behavior without biological accuracy, highlighting risks of overinterpreting such models.

TrieDedup is a trie-based deduplication algorithm that efficiently handles ambiguous bases in high-throughput sequencing by reducing memory usage and increasing speed compared to pairwise comparison methods.

The paper shows that Ku70 suppresses alternative end-joining (A-EJ) in G1-arrested progenitor B cells, directing DSB repair toward classical nonhomologous end-joining (C-NHEJ) and preventing translocations.

The paper identifies enriched neurodegenerative microglia signatures in EVs from Alzheimer's disease mouse models using proteomic analysis.

This study investigates how Alzheimer's disease-derived extracellular vesicles propagate tau pathology and affect GABAergic neuronal transmission.