MtDNA heteroplasmy controls tumor immune reprogramming through mitochondrial translation
Ning Liu, Guoshi Chai, Qunyu Lv, Xiaoling Deng, Jiatong Chen, Qian Zhang, Leping Zhang, Xu Liu, Ruolan Tang, Zhe Xu, Shang Cai
The paper shows that mtDNA heteroplasmy regulates tumor progression by modulating mitochondrial translation and immune microenvironment remodeling through the LARS2-S100A8/A9 axis.
bioRxiv · Feb 3, 2026 · PreprintCancer Biology