Nina Adler

The paper identifies mutational signatures in cancer genomes that alter protein sequence motifs in signaling networks, linking mutation etiology to functional consequences.

The paper identifies TOP2B binding sites as mutational hotspots in cancer genomes, showing their role in structural variants and driver mutations in genes like TP53 and MYC.

The paper develops polygenic risk scores to stratify lung cancer and smoking cessation risk, showing significant odds ratios in diverse populations and planning clinical trials to evaluate interventions.

The paper identifies exome-wide tandem repeats associated with subcortical volumes and psychiatric symptoms in UK Biobank participants.