Jijo Wilson

Glucocorticoid rhythm disruption drives hyperinsulinaemia in mice through beta cell glucocorticoid receptor signalling

This study shows that disrupting glucocorticoid rhythms in mice causes hyperinsulinaemia through beta cell GR signalling and reduced insulin clearance, highlighting insulin's role in maintaining glucose homeostasis.

High fat diet but not glucocorticoid-induced obesity results in fatty liver

This study compares the effects of high-fat diet and glucocorticoid-induced obesity on metabolic outcomes, finding that the latter prevents fatty liver despite similar adiposity.