Mary N. Teruel

YAP/TAZ-controlled ERK dynamics coordinate progenitor expansion and differentiation commitment

This study shows YAP/TAZ control ERK dynamics to balance progenitor expansion and differentiation by modulating PPARG activation thresholds and Hippo signaling.

Parental B-MYB/FOXM1 controls mitotic E2F to determine daughter cell fate

The paper shows that B-MYB/FOXM1 controls daughter cell fate by regulating mitotic E2F activity through timing of its activation during the cell cycle.

Glucocorticoid rhythm disruption drives hyperinsulinaemia in mice through beta cell glucocorticoid receptor signalling

This study shows that disrupting glucocorticoid rhythms in mice causes hyperinsulinaemia through beta cell GR signalling and reduced insulin clearance, highlighting insulin's role in maintaining glucose homeostasis.

Transient proliferation by reversible YAP and mitogen-control of the cyclin D1/p27 ratio

The paper shows YAP and mitogen signaling regulate the cyclin D1/p27 ratio during G1 phase, determining cell cycle entry or exit through receptor-mediated mechanisms and contact inhibition.

Inactivation of CDK4/6, CDK2, and ERK in G1-phase triggers differentiation commitment

The paper shows that inactivation of CDK4/6, CDK2, and ERK in G1-phase is necessary for irreversible cell cycle exit and differentiation commitment during terminal cell differentiation.

High fat diet but not glucocorticoid-induced obesity results in fatty liver

This study compares the effects of high-fat diet and glucocorticoid-induced obesity on metabolic outcomes, finding that the latter prevents fatty liver despite similar adiposity.

A dynamic HIF1alpha-PPARgamma circuit controls a paradoxical adipocyte regulatory landscape

The paper identifies a dynamic HIF1alpha-PPARgamma circuit that both promotes and represses lipid accumulation during adipogenesis, revealing a mechanism for adipocyte dysfunction in obesity.

Expression variation and covariation impair analog and enable binary signaling control

The paper measures protein expression variability in Xenopus laevis and human cells, showing lower variation than expected and demonstrating how covariation between MEK and ERK improves population-level control of binary cell-fate decisions.