Modular counterplays shape condensation and signaling of chimeric antigen receptor
Yiran Jiang, Zhengxu Ren, Jijun Luo, Haochen Yang, Xiwei Liu, Hui Chen, Chenqi Xu, Jizhong Lou
This study shows that PD-1 disrupts CAR-LCK condensates by binding CAR, and adding a CD3ε module stabilizes these condensates, enhancing CAR T cell activity against solid tumors.
bioRxiv · Jul 30, 2026 · PreprintImmunology