The lipid landscape shapes the immunomodulatory potential of fluoxetine in macrophages
Jill Grondelaers, Ashleigh Jimenez-Lemus, Lieve Temmerman, Erik A.L. Biessen, Ronit Shiri‐Sverdlov, Emiel P. C. van der Vorst, Tom Houben
This study shows that the macrophage lipid landscape influences the immunomodulatory effects of fluoxetine, with lipid alterations affecting its anti-inflammatory potential in treatment-resistant depression.
bioRxiv · Aug 28, 2026 · PreprintImmunology