Targeting Gi/o-coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptans
Jing Peng, Brianna T Sanchez, Anda M. Chirila, Xiangsunze Zeng, Michelle M. DeLisle, Lijun Qi, Jia Yin Xiao, Karina Lezgiyeva, Sarah A. Low, Clifford J. Woolf, Nikhil Sharma, David D. Ginty
The paper identifies Gi/o-coupled GPCRs in nociceptors and shows that Htr1b agonists like triptans reduce neuronal excitability and pain in models, suggesting new analgesic targets.
Cell Reports Medicine · Jul 30, 2026Peer-reviewedNeuroscience