Nikhil Sharma

The paper identifies Gi/o-coupled GPCRs in nociceptors and shows that Htr1b agonists like triptans reduce neuronal excitability and pain in models, suggesting new analgesic targets.

The paper identifies A{delta}-HTMRs as fast-conducting mechanonociceptors that drive protective pain responses through unique spinal reflex circuits.

This study shows that neuronal activity is essential for the development of touch receptors, as genetic disruption of Piezo2 and Nav1.6 leads to structural and functional defects in mechanosensory neurons.

This study identifies how specific enteric neuron populations control intestinal function through genetic manipulation in mice.

The paper identifies distinct subsets of DRG neurons innervating the distal colon with different mechanosensitivity thresholds, showing their role in physiological and pathological responses to colon distension.

The paper develops a genetic toolkit to study DRG neuron subtypes, revealing their molecular, morphological, and functional diversity in response to mechanical and thermal stimuli.