Anda M. Chirila

Targeting Gi/o-coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptans

The paper identifies Gi/o-coupled GPCRs in nociceptors and shows that Htr1b agonists like triptans reduce neuronal excitability and pain in models, suggesting new analgesic targets.

Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PV+ interneurons

This study shows nerve injury disrupts temporal firing patterns in spinal cord dorsal horn neurons, driven by PV+ interneurons, contributing to mechanical allodynia.

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

This study shows that γ-protocadherin isoforms are critical for synapse formation and peripheral branching in touch sensory neurons, and their loss disrupts corticospinal synapses.

Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain

This study shows that spinal cord dorsal horn neurons integrate inputs from multiple mechanoreceptor subtypes, leading to diverse mechanical response profiles and influencing tactile representations in the brain.

NMDA receptor activation induces long-term potentiation of glycine synapses

The paper investigates how NMDA receptor activation leads to long-term potentiation of glycinergic synapses in the spinal cord, potentially enhancing nociceptive signal transmission during injury.