Translational response to mitochondrial stresses is orchestrated by tRNA modifications.
Sherif Rashad, Shadi Al-Mesitef, Abdulrahman Mousa, Yuan Zhou, Daisuke Ando, Guangxin Sun, Tomoko Fukuuchi, Yuko Iwasaki, Jingdong Xiang, Shane R. Byrne, Jingjing Sun, Masamitsu Maekawa, Daisuke Saigusa, Thomas J. Begley, Peter C. Dedon, Kuniyasu Niizuma
The paper shows that tRNA modifications regulate the translational response to mitochondrial stress by altering codon decoding and pathway activity.
bioRxiv · Feb 14, 2024 · PreprintMolecular Biology