Daisuke Saigusa

This study identifies METTL7B as a regulator of lipid metabolism and tumor progression in pancreatic cancer, showing its role in promoting cell proliferation, migration, and metastasis.

This study shows that nuclear MAT2A activity is essential for antibody class switch recombination by maintaining AID expression after germline transcription.

This study shows that cysteine restriction induces ferroptosis in hepatic cancer cells via the polyamine biosynthetic pathway, but not in normal hepatocytes.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

This study evaluates the interlaboratory reproducibility of the MxP(R) Quant 500 metabolomics/lipidomics kit across human and rodent blood samples, showing high consistency and reliability.

The paper shows that tRNA modifications regulate the translational response to mitochondrial stress by altering codon decoding and pathway activity.

This study investigates how transcription and translation repression affect ferroptosis induced by different inhibitors, revealing distinct protective and detrimental effects based on the type of inducer.