Sherif Rashad

This study uses long-read multi-omics sequencing to analyze DNA-to-RNA remodeling in recurrent astrocytoma, identifying patient-specific genetic and epigenetic changes and their impact on RNA isoforms and protein fate.

This study examines how RNA-protein coupling changes in osteocytes under hyperglycemic conditions, revealing post-transcriptional regulation of the proteome.

This study identifies ALKBH1 as a driver of codon-biased translation and tumor microenvironment remodeling in glioma, promoting stemness and immune evasion.

The paper identifies codon bias patterns and tRNA modification indices that influence translational programs in human tissues and cancers, revealing functional divergence and implications for mRNA therapeutics.

This study identifies staged translational remodeling in mouse cortex after ischemic stroke, showing changes in codon usage, ribosome occupancy, and frame-disruption events not captured by transcriptomics.

This study identifies HuR as a key regulator of osteocyte survival and metabolic adaptation under high glucose stress through transcriptome-wide analysis of its function.

The paper analyzes tDRs across seven mouse tissues, identifying tissue-specific enrichment, diversity, and structural features of tDRs.

The paper analyzes alternative splicing changes during neuronal differentiation in SH-SY5Y cells, identifying RNA binding proteins that regulate splicing and influence differentiation and stress response.

The paper shows that tRNA modifications regulate the translational response to mitochondrial stress by altering codon decoding and pathway activity.

This study shows that Angiogenin regulates mitochondrial stress and function by generating tRNA-derived fragments and altering tRNA modifications.

The paper shows that tRNA modifications influence tissue-specific mRNA translation and codon optimization by analyzing tRNA and mRNA data from seven mouse tissues.

The paper investigates mRNA stability changes during neuronal differentiation, revealing a bidirectional regulation and identifying SAMD4A as a key RNA binding protein involved in this process.

This study shows that m6A accumulation correlates more strongly with MAPT pathology than beta-amyloid in an Alzheimer's mouse model.

This study investigates how RNF213 loss of function affects vascular cells, revealing changes in transcriptome and alternative splicing linked to MMD pathogenesis.

The paper investigates transcriptomic and epigenetic changes during neuronal differentiation, finding that mRNA stability and alternative splicing regulate oxidative stress sensitivity in mature neurons.

This study investigates how transcription and translation repression affect ferroptosis induced by different inhibitors, revealing distinct protective and detrimental effects based on the type of inducer.

The paper investigates stress-specific tRNA cleavage patterns, identifying non-canonical cleavage independent of angiogenin and highlighting the role of Alkbh1 in stress type-dependent tRNA cleavage.

This study investigates how Alkbh1 affects tRNA cleavage and tiRNA generation under stress in rat cells, showing stress-specific impacts and differential tRNA cleavage.