A BCG toxic effector induces mitochondrial DNA compaction to refrain protective immunity
Cheng Peng, Chen Qiu, Jingping Huang, Wenyi Bu, Xuan Wu, Yongjia Duan, Shanshan Liu, Hongyu Cheng, Mingtong Ma, YUANNA N. CHENG, Jingxiang Wang, Hua Yang, Ruijuan Zheng, Jie Wang, Xiaochen Huang, , Baoxue Ge
This study shows that BCG effector PE18 induces mitochondrial DNA compaction to suppress trained immunity and protective immunity against Mtb.
bioRxiv · Nov 9, 2025 · PreprintImmunology