Yongjia Duan

Reconstitution of multistep recruitment of ULK1 to membranes in autophagy

This study identifies a stepwise pathway for ULK1 recruitment to membranes during autophagy, involving WIPI proteins and a PVP motif in ULK1.

Structural basis for the selective inhibition of the PI3KC3-C2 complex by Rubicon in endolysosome maturation and mitophagy

This paper determines the cryo-EM structure of the PI3KC3-C2 complex with Rubicon's PIKBD domain, revealing how Rubicon selectively inhibits PI3KC3-C2 to regulate endolysosome maturation and mitophagy.

A BCG toxic effector induces mitochondrial DNA compaction to refrain protective immunity

This study shows that BCG effector PE18 induces mitochondrial DNA compaction to suppress trained immunity and protective immunity against Mtb.

CHMP2B regulates TDP-43 phosphorylation and proteotoxicity via modulating CK1 turnover independent of the autophagy-lysosomal pathway

This study identifies CHMP2B as a regulator of TDP-43 phosphorylation and proteotoxicity through CK1 turnover, independent of autophagy-lysosomal pathways in neurodegenerative diseases.

Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation

The paper shows stress induces TDP-43 nuclear bodies via NEAT1-promoted phase separation, which protects cells from toxicity and is disrupted by an ALS mutation.

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.