Stephanie L. Moon

Temporal gating dictates stress-induced transcript export from the nucleus

The paper shows that transcription timing, not sequence features, determines nuclear export of stress-induced mRNAs in human cells.

ASPL-driven subunit exchange remodels VCP/p97 hexamers and is impaired by a multisystem proteinopathy mutation

The paper quantifies VCP hexamer assembly and subunit exchange dynamics, showing that the R155H mutation impairs ASPL-mediated exchange, potentially stabilizing mutant VCP in assemblies.

Npl4 decodes polyubiquitin length and gates D1-D2 coupling in human VCP/p97

This study investigates how Npl4 decodes polyubiquitin chain length and regulates D1-D2 coupling in human VCP/p97 using smUbiRAD, revealing chain-length thresholds and disease-linked mutations.

tRNA synthetase activity is required for stress granule and P-body assembly

This study shows tRNA synthetase activity is required for ribosome runoff during stress to drive RNP granule assembly, but not for stress granule or P-body formation.

Coupling of translation quality control and mRNA targeting to stress granules

The paper investigates how defects in the ubiquitin-proteasome system affect mRNA translation and partitioning into stress granules during acute stress.

Imaging of single mRNA translation repression reveals diverse interactions with mRNP granules

The paper images single mRNA interactions with stress granules and P-bodies during stress, showing dynamic and stable associations influenced by mRNA length and granule size.