DSB repair kinetics impair CRISPR-Cas9 editing in human embryos
Dieter M. Egli, Diego Marin, Nathan R. Treff, Stepan Jerabek, Julie Sung, Jia L. Xu, Jishnu Talukdar
This study shows that CRISPR-Cas9 editing in human embryos is limited by slow DSB repair kinetics, leading to mosaicism and chromosomal abnormalities.
bioRxiv · May 7, 2025 · PreprintDevelopmental Biology