Efficient base editing and development in human embryos without chromosomal alterations
Stepan Jerabek, Jimin Kim, Julie Sung, Chanju Jung, Marcos Iuri Roos Kulmann, Melisa Isado, Hong-Su Jang, Meng Li, Sakshi Bhatele, Michelle D. Kappy, Shuangyi Xu, Gue‐Ho Hwang, Jia L. Xu, Diego Marin, Jae‐Sung Woo, , Dieter M. Egli
This study shows that base editing in human embryos produces efficient on-target changes without chromosomal abnormalities or large deletions, unlike CRISPR/Cas9-induced DSBs.
bioRxiv · Jun 1, 2026 · PreprintGenetics