Author

Diego Marin

Rutgers, The State University of New JerseyORCID 0000-0002-5445-6973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Dieter M. EgliiD· 3 shared Jia L. XuiD· 3 shared Nathan R. TreffiD· 3 shared Jimin Kim· 2 shared Julie Sung· 2 shared Shuangyi XuiD· 2 shared Stepan JerabekiD· 2 shared Alex RoblesiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersDevelopmental Biology

Dieter M. EgliORCID

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3 papers

Recent·Most cited

DNA Double Strand Breaks cause chromosome loss through sister chromatid tethering in human embryos

Jenna M. Turocy, Stepan Jerabek, Woonyung Hur, Jimin Kim, Shuangyi Xu, Qiaojin Zhao, Jia L. Xu, Alex Robles, Xiangyi Liu, Nathan R. Treff, Diego Marin, Anna‐Katerina Hadjantonakis, Dieter M. Egli

This study shows that DNA double-strand breaks in human embryos lead to chromosome loss through sister chromatid tethering and centromere-mediated separation.

Nature Communications · Jun 3, 2026Peer-reviewedDevelopmental Biology

Efficient base editing and development in human embryos without chromosomal alterations

Stepan Jerabek, Jimin Kim, Julie Sung, Chanju Jung, Marcos Iuri Roos Kulmann, Melisa Isado, Hong-Su Jang, Meng Li, Sakshi Bhatele, Michelle D. Kappy, Shuangyi Xu, Gue‐Ho Hwang, Jia L. Xu, Diego Marin, Jae‐Sung Woo, , Dieter M. Egli

This study shows that base editing in human embryos produces efficient on-target changes without chromosomal abnormalities or large deletions, unlike CRISPR/Cas9-induced DSBs.

bioRxiv · Jun 1, 2026 · PreprintGenetics

DSB repair kinetics impair CRISPR-Cas9 editing in human embryos

Dieter M. Egli, Diego Marin, Nathan R. Treff, Stepan Jerabek, Julie Sung, Jia L. Xu, Jishnu Talukdar

This study shows that CRISPR-Cas9 editing in human embryos is limited by slow DSB repair kinetics, leading to mosaicism and chromosomal abnormalities.

bioRxiv · May 7, 2025 · PreprintDevelopmental Biology