Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness of Enterococcus faecalis
Soumaya Zlitni, Sierra Bowden, Hila Sberro, Marcelo D. T. Torres, Joan M. Vaughan, Antônio F. M. Pinto, Yishay Pinto, Daniel Fernández, Hannes Luc Röst, Alan Saghatelian, César de la Fuente‐Núñez, Ami Siddharth Bhatt
This study identifies two quorum-sensing systems in E. faecalis that regulate purine biosynthesis, enhancing its pathogenicity in macrophages and murine infections.
bioRxiv · Aug 13, 2024 · PreprintMicrobiology