Inactivation of the RB1 and PTPN14 tumor suppressors cooperatively enables the lifespan extension activity of the human papillomavirus E7 oncoprotein
Pushkal Sinduvadi Ramesh, Angelo A. Nicolaci, Leah E Graham, Joangela Nouel, Kevin Xu, Jennifer M. Binning, Karl Münger, Elizabeth A White
This study shows that high-risk HPV E7 proteins require inactivating both RB1 and PTPN14 to extend keratinocyte lifespan, while low-risk E7 needs PTPN14 inactivation alone.
bioRxiv · Aug 17, 2026 · PreprintMicrobiology