Kevin Xu

Inactivation of the RB1 and PTPN14 tumor suppressors cooperatively enables the lifespan extension activity of the human papillomavirus E7 oncoprotein

This study shows that high-risk HPV E7 proteins require inactivating both RB1 and PTPN14 to extend keratinocyte lifespan, while low-risk E7 needs PTPN14 inactivation alone.

Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty

The paper investigates how perceptual novelty and reward value interact in decision-making by identifying a neural pathway between the anterior ventral temporal cortex and orbitofrontal cortex.

Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics

The paper engineers hTRPV4 to create an ultrasound-sensitive actuator for sonogenetics, showing improved mechano-sensitivity and reduced sensitivity to other stimuli.