Joann Sweasy

DNA Polymerase Beta Catalytic and Fidelity Mutations Drive Platinum Specific Drug Sensitivity

This study identifies Polβ mutations that drive sensitivity to cisplatin and carboplatin in TNBC models, suggesting their use as predictive biomarkers for platinum-based therapies.

DNA polymerase β fingers movement revealed by single-molecule FRET suggests a partially closed conformation as a fidelity checkpoint

This study uses single-molecule FRET to analyze DNA polymerase β conformational changes, revealing a partially closed fingers conformation as a fidelity checkpoint during DNA repair.