Jacob Lindquist

DNA Polymerase Beta Catalytic and Fidelity Mutations Drive Platinum Specific Drug Sensitivity

This study identifies Polβ mutations that drive sensitivity to cisplatin and carboplatin in TNBC models, suggesting their use as predictive biomarkers for platinum-based therapies.

Targeting SCD in SCD-amplified prostate cancer inhibits growth in bone by modulating cellular stress, mTOR, and DNA damage pathways

This study shows SCD inhibition in prostate cancer reduces tumor growth in bone by affecting cellular stress, mTOR, and DNA damage pathways.