Joshua R. Heyza

This study identifies Polβ mutations that drive sensitivity to cisplatin and carboplatin in TNBC models, suggesting their use as predictive biomarkers for platinum-based therapies.

This study uses Cas12a-based knockout screens to identify genetic interactions in the DNA damage response, revealing synthetic lethal and buffering interactions with therapeutic implications.

The paper identifies a conserved mechanism preventing replication restart from RNA:DNA hybrids in bacteria and mammals.

This study shows the PST repeat region of MDC1 is a multivalent chromatin tethering domain with tunable affinity that aids in DNA break tethering during HR and mitosis.

This study identifies MMEJ as the primary DSB repair pathway in mitosis and reveals RHINO's role in directing mutagenic repair to M phase.