STAT3 phosphorylation in the rheumatoid arthritis immunological synapse
Hila Novak‐Kotzer, Jesusa Capera, Ashwin Jainarayanan, Viveka Mayya, Alexandra Zanin‐Zhorov, Salvatore Valvo, Joanne Macdonald, Peter Charles Taylor, Michael Loran Dustin
This study identifies a JAK-independent mechanism of STAT3 activation in RA through TCR-dependent phosphorylation at the immunological synapse, suggesting a new therapeutic target.
bioRxiv · Jan 20, 2025 · PreprintImmunology