Pharmacological GCase Activity Enhancement Inhibits Tau Accumulation
Matteo Ciccaldo, Natàlia Pérez‐Carmona, Ester Piovesana, Sara Cano‐Crespo, Ana Ruano, Aida Delgado, Ilaria Fregno, Beatriz Calvo‐Flores Guzmán, Manolo Bellotto, Maurizio Molinari, Joanne Taylor, Stéphanie Papin, Ana María García-Collazo, Paolo Paganetti
The paper shows that increasing GCase activity reduces Tau accumulation in fibroblasts with GBA1 mutations, suggesting it could be a therapeutic strategy for neurodegenerative diseases.
Scientific Reports · May 21, 2025Peer-reviewedCell Biology