Matteo Ciccaldo

The paper shows that increasing GCase activity reduces Tau accumulation in fibroblasts with GBA1 mutations, suggesting it could be a therapeutic strategy for neurodegenerative diseases.

This study finds that high Tau expression in Ewing sarcoma cells reduces invasion and improves patient survival.

The paper screens FDA-approved drugs and natural compounds to identify aminoglycoside antibiotics that inhibit the Tau/MDM2 interaction, potentially reducing P53-dependent cell damage in neurodegenerative diseases.