Paolo Paganetti

The paper shows that increasing GCase activity reduces Tau accumulation in fibroblasts with GBA1 mutations, suggesting it could be a therapeutic strategy for neurodegenerative diseases.

This study finds that high Tau expression in Ewing sarcoma cells reduces invasion and improves patient survival.

The paper investigates the association between Parkinson's disease genes and cancer outcomes, finding gene-specific survival correlations and links to cancer hallmarks and drug responses.

The paper screens FDA-approved drugs and natural compounds to identify aminoglycoside antibiotics that inhibit the Tau/MDM2 interaction, potentially reducing P53-dependent cell damage in neurodegenerative diseases.

This study uses longitudinal whole-brain imaging to show that anti-Aβ therapies have distinct spatial and temporal efficacies, with polythiophenes showing strong Aβ clearance.