Author

Manolo Bellotto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Aida DelgadoiD· 2 shared Ana María García-CollazoiD· 2 shared Ana Ruano· 2 shared Ilaria FregnoiD· 2 shared Maurizio MolinariiD· 2 shared Natàlia Pérez‐CarmonaiD· 2 shared Beatriz Calvo‐Flores Guzmán· 1 shared Elena CuberoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCell Biology

Aida DelgadoORCID

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Author profile →

2 papers

Recent·Most cited

Pharmacological GCase Activity Enhancement Inhibits Tau Accumulation

Matteo Ciccaldo, Natàlia Pérez‐Carmona, Ester Piovesana, Sara Cano‐Crespo, Ana Ruano, Aida Delgado, Ilaria Fregno, Beatriz Calvo‐Flores Guzmán, Manolo Bellotto, Maurizio Molinari, Joanne Taylor, Stéphanie Papin, Ana María García-Collazo, Paolo Paganetti

The paper shows that increasing GCase activity reduces Tau accumulation in fibroblasts with GBA1 mutations, suggesting it could be a therapeutic strategy for neurodegenerative diseases.

Scientific Reports · May 21, 2025Peer-reviewedCell Biology

A novel class of allosteric glucosylceramidase beta 1 correctors that reduce cellular stress and enhance lysosomal function

Ilaria Fregno, Natàlia Pérez‐Carmona, Mikhail Rudinskiy, Tatiana Soldà, Timothy Jan Bergmann, Ana Ruano, Aida Delgado, Elena Cubero, Manolo Bellotto, Ana María García-Collazo, Maurizio Molinari

This paper develops two allosteric GCase correctors that improve folding and lysosomal function in GD patient fibroblasts, reducing cellular stress and offering potential therapy for GD, PD, and Dementia with Lewy Bodies.

International Journal of Molecular Sciences · May 6, 2025Peer-reviewedCell Biology